Spathodea companulata (African tulip tree) stem and root barks extracts ameliorated N-nitroso diethylamine induced hepatic impairment in male rats

Spathodea campanulata Beauv. is an important plant widely used in traditional medicine for the treatment of hepatic disease. In present study, we evaluate phytochemical composition and hepatoprotective potential effect stem root bark extracts companulata on dimethylnitrosamine (DEN) induced impairment albino rats. Phytochemical compositions were analyzed using standard protocols. Forty-five male rats grouped into 9 (A-I) 5 each. Groups A-F treated with extract, quercetin, DEN + quercetin respectively while groups G-1 serve as control corn oil only (Vehicle control), (Toxicant distilled water (normal control) respectively. was given at 25 mg/kg b.w., i.p a weekly basis all treatments administered 100 BW orally 60 days. Serum transaminase activities, body weight, liver weight ratio evaluated. Results revealed presence alkaloids, cardiac glycoside, saponins, anthraquinone, steroids, flavonoids extract companulata, contains anthraquinonoid, flavonoid. The non-treated rat exhibited significant (p<0.05) loss increase serum alanine (ALT) aspartate (AST) activities when compared normal control. Treatment significantly ameliorated toxicant induce alterations activity nontreated conclusion, this study provides scientific validation use management disorders